Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

The ruthenium compound KP1019 has demonstrated promising anticancer activity in a pilot clinical trial. This study aims to evaluate the intracellular uptake/binding patterns of KP1019 and its sodium salt KP1339, which is currently in a phase I–IIa study. Although KP1339 tended to be moderately less...

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Bibliografiske detaljer
Main Authors: Heffeter, Petra, Böck, Katharina, Atil, Bihter, Hoda, Mir Ali Reza, Körner, Wilfried, Bartel, Caroline, Jungwirth, Ute, Keppler, Bernhard K., Micksche, Michael, Berger, Walter, Koellensperger, Gunda
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371400/
https://ncbi.nlm.nih.gov/pubmed/20221888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-010-0642-1
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