4-Hydroxy-2-Nonenal Mediates Genotoxicity and Bystander Effects Caused by Enterococcus faecalis-Infected Macrophages

BACKGROUND & AIMS: Enterococcus faecalis is a human intestinal commensal that produces extracellular superoxide and promotes chromosome instability via macrophage-induced bystander effects. We investigated the ability of 4-hydroxy-2-nonenal (4-HNE)—a diffusible breakdown product of ω-6 polyunsat...

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Bibliografiske detaljer
Main Authors: Wang, Xingmin, Yang, Yonghong, Moore, Danny R., Nimmo, Susan L., Lightfoot, Stanley A., Huycke, Mark M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371374/
https://ncbi.nlm.nih.gov/pubmed/22108198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.11.020
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