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Protein Sequence Alignment Analysis by Local Covariation: Coevolution Statistics Detect Benchmark Alignment Errors

The use of sequence alignments to understand protein families is ubiquitous in molecular biology. High quality alignments are difficult to build and protein alignment remains one of the largest open problems in computational biology. Misalignments can lead to inferential errors about protein structu...

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Библиографические подробности
Главные авторы: Dickson, Russell J., Gloor, Gregory B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371027/
https://ncbi.nlm.nih.gov/pubmed/22715369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037645
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