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Identifying and Seeing beyond Multiple Sequence Alignment Errors Using Intra-Molecular Protein Covariation

BACKGROUND: There is currently no way to verify the quality of a multiple sequence alignment that is independent of the assumptions used to build it. Sequence alignments are typically evaluated by a number of established criteria: sequence conservation, the number of aligned residues, the frequency...

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Autors principals: Dickson, Russell J., Wahl, Lindi M., Fernandes, Andrew D., Gloor, Gregory B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893159/
https://ncbi.nlm.nih.gov/pubmed/20596526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011082
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