A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus

The removal of chemically damaged DNA bases such as 3-methyladenine (3-­MeA) is an essential process in all living organisms and is catalyzed by the enzyme 3-MeA DNA glycosylase I. A key question is how the enzyme selectively recognizes the alkylated 3-MeA over the much more abundant adenine. The cr...

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Main Authors: Zhu, Xiaofeng, Yan, Xuan, Carter, Lester G., Liu, Huanting, Graham, Shirley, Coote, Peter J., Naismith, James
פורמט: Artigo
שפה:Inglês
יצא לאור: International Union of Crystallography 2012
נושאים:
Structural Communications
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370894/
https://ncbi.nlm.nih.gov/pubmed/22684054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112016363
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