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Divalent Metals and pH Alter Raltegravir Disposition In Vitro
Raltegravir shows marked pharmacokinetic variability in patients, with gastrointestinal pH and divalent-metal binding being potential factors. We investigated raltegravir solubility, lipophilicity, pK(a), and permeativity in vitro to elucidate known interactions with omeprazole, antacids, and food,...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3370743/ https://ncbi.nlm.nih.gov/pubmed/22450971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06407-11 |
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