The Aminoglycoside Antibiotic Kanamycin Damages DNA Bases in Escherichia coli: Caffeine Potentiates the DNA-Damaging Effects of Kanamycin while Suppressing Cell Killing by Ciprofloxacin in Escherichia coli and Bacillus anthracis

The distribution of mutants in the Keio collection of Escherichia coli gene knockout mutants that display increased sensitivity to the aminoglycosides kanamycin and neomycin indicates that damaged bases resulting from antibiotic action can lead to cell death. Strains lacking one of a number of glyco...

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Hauptverfasser: Kang, Tina Manzhu, Yuan, Jessica, Nguyen, Angelyn, Becket, Elinne, Yang, Hanjing, Miller, Jeffrey H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370725/
https://ncbi.nlm.nih.gov/pubmed/22391551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00066-12
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