Population Pharmacokinetic Analysis and Pharmacogenetics of Raltegravir in HIV-Positive and Healthy Individuals

The objectives of this study were to characterize raltegravir (RAL) population pharmacokinetics in HIV-positive (HIV(+)) and healthy individuals, identify influential factors, and search for new candidate genes involved in UDP glucuronosyltransferase (UGT)-mediated glucuronidation. The pharmacokinet...

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Main Authors: Arab-Alameddine, Mona, Fayet-Mello, Aurélie, Lubomirov, Rubin, Neely, Michael, di Iulio, Julia, Owen, Andrew, Boffito, Marta, Cavassini, Matthias, Günthard, Huldrych F., Rentsch, Katharina, Buclin, Thierry, Aouri, Manel, Telenti, Amalio, Decosterd, Laurent Arthur, Rotger, Margalida, Csajka, Chantal
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370715/
https://ncbi.nlm.nih.gov/pubmed/22371894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05424-11
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