Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer

Crigler-Najjar type I (CNI) syndrome is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia caused by uridine diphosphoglucuronosyltransferase 1A1 (UGT1A1) deficiency. The disease is lethal due to bilirubin-induced neurological damage unless phototherapy is appli...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Bortolussi, Giulia, Zentilin, Lorena, Baj, Gabriele, Giraudi, Pablo, Bellarosa, Cristina, Giacca, Mauro, Tiribelli, Claudio, Muro, Andrés F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2012
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370676/
https://ncbi.nlm.nih.gov/pubmed/22094718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-195461
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky