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Development of a Single-Gene, Signature-Tag-Based Approach in Combination with Alanine Mutagenesis To Identify Listeriolysin O Residues Critical for the In Vivo Survival of Listeria monocytogenes

Listeriolysin O (LLO) is a pore-forming toxin of the cholesterol-dependent cytolysin (CDC) family and a primary virulence factor of the intracellular pathogen Listeria monocytogenes. LLO mediates rupture of phagosomal membranes, thereby releasing bacteria into the growth-permissive host cell cytosol...

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Detalhes bibliográficos
Main Authors: Melton-Witt, Jody A., McKay, Susannah L., Portnoy, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370594/
https://ncbi.nlm.nih.gov/pubmed/22451517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06196-11
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