Neutralizing Antibodies Elicited by a Novel Detoxified Pneumolysin Derivative, PlyD1, Provide Protection against Both Pneumococcal Infection and Lung Injury

Streptococcus pneumoniae pneumolysin (PLY) is a virulence factor that causes toxic effects contributing to pneumococcal pneumonia. To date, deriving a PLY candidate vaccine with the appropriate detoxification and immune profile has been challenging. A pneumolysin protein that is appropriately detoxi...

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Detalhes bibliográficos
Main Authors: Salha, Danielle, Szeto, Jason, Myers, Lisa, Claus, Carol, Sheung, Anthony, Tang, Mei, Ljutic, Belma, Hanwell, David, Ogilvie, Karen, Ming, Marin, Messham, Benjamin, van den Dobbelsteen, Germie, Hopfer, Robert, Ochs, Martina M., Gallichan, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370579/
https://ncbi.nlm.nih.gov/pubmed/22473606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06348-11
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