A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

Androgens control spermatogenesis, but germ cells themselves do not express a functional androgen receptor (AR). Androgen regulation is thought to be mediated by Sertoli and peritubular myoid cells, but their relative roles and the mechanisms involved remain largely unknown. Using Cre/loxP technolog...

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Autors principals: De Gendt, Karel, Swinnen, Johannes V., Saunders, Philippa T. K., Schoonjans, Luc, Dewerchin, Mieke, Devos, Ann, Tan, Karen, Atanassova, Nina, Claessens, Frank, Lécureuil, Charlotte, Heyns, Walter, Carmeliet, Peter, Guillou, Florian, Sharpe, Richard M., Verhoeven, Guido
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC337052/
https://ncbi.nlm.nih.gov/pubmed/14745012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308114100
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