Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: A mechanism for generation of soluble cytokine receptors

Soluble tumor necrosis factor receptors (TNFRs) are important modulators of TNF bioactivity. Proteolytic cleavage of the 28-kDa ectodomain of TNFR1 has been recognized as the mechanism by which soluble TNFR is shed. We now describe the release of exosome-like vesicles as a mechanism for the generati...

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Main Authors: Hawari, Feras I., Rouhani, Farshid N., Cui, Xinle, Yu, Zu-Xi, Buckley, Caitriona, Kaler, Maryann, Levine, Stewart J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2004
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC337047/
https://ncbi.nlm.nih.gov/pubmed/14745008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307981100
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