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DNA–PKcs function regulated specifically by protein phosphatase 5

Unrepaired DNA double-strand breaks can lead to apoptosis or tumorigenesis. In mammals double-strand breaks are repaired mainly by nonhomologous end-joining mediated by the DNA–PK complex. The core protein of this complex, DNA–PKcs, is a DNA-dependent serine/threonine kinase that phosphorylates prot...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wechsler, Thomas, Chen, Benjamin P. C., Harper, Ryan, Morotomi-Yano, Keiko, Huang, Betty C. B., Meek, Katheryn, Cleaver, James E., Chen, David J., Wabl, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC337038/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14734805/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307765100
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