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DNA–PKcs function regulated specifically by protein phosphatase 5
Unrepaired DNA double-strand breaks can lead to apoptosis or tumorigenesis. In mammals double-strand breaks are repaired mainly by nonhomologous end-joining mediated by the DNA–PK complex. The core protein of this complex, DNA–PKcs, is a DNA-dependent serine/threonine kinase that phosphorylates prot...
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Main Authors: | , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
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National Academy of Sciences
2004
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC337038/ https://ncbi.nlm.nih.gov/pubmed/14734805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307765100 |
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