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Mechanism-based population pharmacokinetic modelling in diabetes: vildagliptin as a tight binding inhibitor and substrate of dipeptidyl peptidase IV

AIMS: To assess the pharmacokinetics of vildagliptin at different doses and build a mechanism-based population model that simultaneously describes vildagliptin pharmacokinetics and its effects on DPP-4 activity based on underlying physiology and biology. METHODS: Vildagliptin concentrations and DPP-...

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Bibliografiske detaljer
Main Authors: Landersdorfer, Cornelia B, He, Yan-Ling, Jusko, William J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370343/
https://ncbi.nlm.nih.gov/pubmed/22442826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04108.x
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