Evaluation of pharmacokinetic parameters and dipeptidyl peptidase-4 inhibition following single doses of sitagliptin in healthy, young Japanese males

AIMS: Sitagliptin is a selective inhibitor of dipeptidyl peptidase-4 (DPP-4) used to treat type 2 diabetes. The present aim was to evaluate pharmacokinetic (PK), pharmacodynamic (PD) and safety characteristics of sitagliptin following single doses in healthy, young Japanese males. METHODS: In this a...

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Detalhes bibliográficos
Main Authors: Herman, Gary A, Mistry, Goutam C, Yi, Bingming, Bergman, Arthur J, Wang, Amy Q, Zeng, Wei, Chen, Li, Snyder, Karen, Ruckle, Jon L, Larson, Patrick J, Davies, Michael J, Langdon, Ronald B, Gottesdiener, Keith M, Wagner, John A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045552/
https://ncbi.nlm.nih.gov/pubmed/21284702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03852.x
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