Evaluation of pharmacokinetic parameters and dipeptidyl peptidase-4 inhibition following single doses of sitagliptin in healthy, young Japanese males

AIMS: Sitagliptin is a selective inhibitor of dipeptidyl peptidase-4 (DPP-4) used to treat type 2 diabetes. The present aim was to evaluate pharmacokinetic (PK), pharmacodynamic (PD) and safety characteristics of sitagliptin following single doses in healthy, young Japanese males. METHODS: In this a...

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Autors principals: Herman, Gary A, Mistry, Goutam C, Yi, Bingming, Bergman, Arthur J, Wang, Amy Q, Zeng, Wei, Chen, Li, Snyder, Karen, Ruckle, Jon L, Larson, Patrick J, Davies, Michael J, Langdon, Ronald B, Gottesdiener, Keith M, Wagner, John A
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2011
Matèries:
Pharmacokinetic Dynamic Relationships
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045552/
https://ncbi.nlm.nih.gov/pubmed/21284702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03852.x
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