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Tumor Suppressors p53, p63TAα, p63TAy, p73α, and p73β Use Distinct Pathways to Repress Telomerase Expression
The promoter of the telomerase catalytic subunit (TERT) is subject to tight regulation and remains repressed in somatic cells to ensure their limited life span and to prevent tumor initiation. Here we report that the hTERT promoter is strongly repressed by p53 and the related family members p63 and...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3370256/ https://ncbi.nlm.nih.gov/pubmed/22496369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319236 |
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