Multiple Cholesterol Recognition/Interaction Amino Acid Consensus (CRAC) Motifs in Cytosolic C Tail of Slo1 Subunit Determine Cholesterol Sensitivity of Ca(2+)- and Voltage-gated K(+) (BK) Channels

Large conductance, Ca(2+)- and voltage-gated K(+) (BK) channel proteins are ubiquitously expressed in cell membranes and control a wide variety of biological processes. Membrane cholesterol regulates the activity of membrane-associated proteins, including BK channels. Cholesterol modulation of BK ch...

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Bibliographic Details
Main Authors: Singh, Aditya K., McMillan, Jacob, Bukiya, Anna N., Burton, Brittany, Parrill, Abby L., Dopico, Alex M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370236/
https://ncbi.nlm.nih.gov/pubmed/22474334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356261
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