Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca(2+)-sensitive Organellar Two-pore Channel TPC1

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent second messenger that mobilizes Ca(2+) from the acidic endolysosomes by activation of the two-pore channels TPC1 and TPC2. The channel properties of human TPC1 have not been studied before, and its cellular function is not known. In t...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Rybalchenko, Volodymyr, Ahuja, Malini, Coblentz, Jessica, Churamani, Dev, Patel, Sandip, Kiselyov, Krill, Muallem, Shmuel
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2012
الموضوعات:
Membrane Biology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370221/
https://ncbi.nlm.nih.gov/pubmed/22500018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359612
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