Crystal Structure of Escherichia coli Diaminopropionate Ammonia-lyase Reveals Mechanism of Enzyme Activation and Catalysis

Pyridoxal 5′-phosphate (PLP)-dependent enzymes utilize the unique chemistry of a pyridine ring to carry out diverse reactions involving amino acids. Diaminopropionate (DAP) ammonia-lyase (DAPAL) is a prokaryotic PLP-dependent enzyme that catalyzes the degradation of d- and l-forms of DAP to pyruvate...

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Bibliographic Details
Main Authors: Bisht, Shveta, Rajaram, Venkatesan, Bharath, Sakshibeedu R., Kalyani, Josyula Nitya, Khan, Farida, Rao, Appaji N., Savithri, Handanahal S., Murthy, Mathur R. N.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370218/
https://ncbi.nlm.nih.gov/pubmed/22505717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.351809
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