Discovery of Critical Residues for Viral Entry and Inhibition through Structural Insight of HIV-1 Fusion Inhibitor CP621–652

The core structure of HIV-1 gp41 is a stable six-helix bundle (6-HB) folded by its trimeric N- and C-terminal heptad repeats (NHR and CHR). We previously identified that the (621)QIWNNMT(627) motif located at the upstream region of gp41 CHR plays critical roles for the stabilization of the 6-HB core...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Chong, Huihui, Yao, Xue, Qiu, Zonglin, Qin, Bo, Han, Ruiyun, Waltersperger, Sandro, Wang, Meitian, Cui, Sheng, He, Yuxian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370210/
https://ncbi.nlm.nih.gov/pubmed/22511760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354126
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker