Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction

Sepsis is a major health problem in the United States with high incidence and elevated patient care cost. Using an animal model of sepsis, cecum ligation, and puncture, we observed that mice became rapidly hypothermic reaching a threshold temperature of 28 °C within 5–10 h after initiation of the in...

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Main Authors: Cauvi, David M., Song, Donghuan, Vazquez, Daniel E., Hawisher, Dennis, Bermudez, Jose A., Williams, Michael R., Bickler, Stephen, Coimbra, Raul, De Maio, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370166/
https://ncbi.nlm.nih.gov/pubmed/22518839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359562
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