Period of Irreversible Therapeutic Intervention during Sepsis Correlates with Phase of Innate Immune Dysfunction

Sepsis is a major health problem in the United States with high incidence and elevated patient care cost. Using an animal model of sepsis, cecum ligation, and puncture, we observed that mice became rapidly hypothermic reaching a threshold temperature of 28 °C within 5–10 h after initiation of the in...

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Detalhes bibliográficos
Main Authors: Cauvi, David M., Song, Donghuan, Vazquez, Daniel E., Hawisher, Dennis, Bermudez, Jose A., Williams, Michael R., Bickler, Stephen, Coimbra, Raul, De Maio, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370166/
https://ncbi.nlm.nih.gov/pubmed/22518839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359562
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