Characterization of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as Novel Leads to Development of Mu Opioid Receptor Selective Antagonists

[Image: see text] As important pharmacological probes, highly selective opioid receptor antagonists are essential in opioid receptor structural characterization and opioid agonist functional studies. At present, a nonpeptidyl, highly selective, and reversible mu opioid receptor antagonist is still n...

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Detalhes bibliográficos
Main Authors: Yuan, Yunyun, Li, Guo, He, Hengjun, Stevens, David L., Kozak, Patrick, Scoggins, Krista L., Mitra, Pallabi, Gerk, Phillip M., Selley, Dana E., Dewey, William L., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369747/
https://ncbi.nlm.nih.gov/pubmed/22816021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn2000348
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