Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists

[Image: see text] A series of 3-substituted aminocyclopentanes has been identified as highly potent and selective NR2B receptor antagonists. Incorporation of a 1,2,4-oxadiazole linker and substitution of the pendant phenyl ring led to the discovery of orally bioavailable analogues that showed effici...

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Hauptverfasser: Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2011
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369735/
https://ncbi.nlm.nih.gov/pubmed/22816022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200013d
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