Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach

Maraviroc (MVC) is the first licensed antiretroviral drug from the class of coreceptor antagonists. It binds to the host coreceptor CCR5, which is used by the majority of HIV strains in order to infect the human immune cells (Fig. 1). Other HIV isolates use a different coreceptor, the CXCR4. Which r...

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Bibliographic Details
Main Authors: Sierra, Saleta, Kaiser, Rolf, Lübke, Nadine, Thielen, Alexander, Schuelter, Eugen, Heger, Eva, Däumer, Martin, Reuter, Stefan, Esser, Stefan, Fätkenheuer, Gerd, Pfister, Herbert, Oette, Mark, Lengauer, Thomas
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2011
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369655/
https://ncbi.nlm.nih.gov/pubmed/22157596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/3264
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