p38 MAPK Activation Promotes Denervated Schwann Cell Phenotype and Functions as a Negative Regulator of Schwann Cell Differentiation and Myelination

Physical damage to the peripheral nerves triggers Schwann cell injury response in the distal nerves in an event termed Wallerian degeneration: the Schwann cells degrade their myelin sheaths and dedifferentiate, reverting to a phenotype that supports axon regeneration and nerve repair. The molecular...

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Detalhes bibliográficos
Main Authors: Yang, David P., Kim, Jihyun, Syed, Neeraja, Tung, Young-john, Bhaskaran, Ambily, Mindos, Thomas, Mirsky, Rhona, Jessen, Kristjan R., Maurel, Patrice, Parkinson, David B., Kim, Haesun A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369433/
https://ncbi.nlm.nih.gov/pubmed/22623660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5812-11.2012
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