Increased Expression of Nox1 in Neointimal Smooth Muscle Cells Promotes Activation of Matrix Metalloproteinase-9

OBJECTIVE: Vascular injury causes neointimal hypertrophy, which is characterized by redox-mediated matrix degradation and smooth muscle cell (SMC) migration and proliferation. We hypothesized that, as compared to the adjacent medial SMCs, neointimal SMCs produce increased superoxide via NADPH oxidas...

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Detalhes bibliográficos
Main Authors: Xu, Shaoping, Shriver, Amy S., Jagadeesha, Dammanahalli K., Chamseddine, Ali H., Szőcs, Katalin, Weintraub, Neal L., Griendling, Kathy K., Bhalla, Ramesh C., Miller, Francis J.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369242/
https://ncbi.nlm.nih.gov/pubmed/22433789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000332958
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