Pharmacokinetic-Pharmacodynamic Modeling of the D(2) and 5-HT(2A) Receptor Occupancy of Risperidone and Paliperidone in Rats

PURPOSE: A pharmacokinetic-pharmacodynamic (PK-PD) model was developed to describe the time course of brain concentration and dopamine D(2) and serotonin 5-HT(2A) receptor occupancy (RO) of the atypical antipsychotic drugs risperidone and paliperidone in rats. METHODS: A population approach was util...

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Main Authors: Kozielska, Magdalena, Johnson, Martin, Pilla Reddy, Venkatesh, Vermeulen, An, Li, Cheryl, Grimwood, Sarah, de Greef, Rik, Groothuis, Geny M. M., Danhof, Meindert, Proost, Johannes H.
格式: Artigo
語言:Inglês
出版: Springer US 2012
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369128/
https://ncbi.nlm.nih.gov/pubmed/22437487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0722-8
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