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Tissue-Specific Responses of IGF-1/Insulin and mTOR Signaling in Calorie Restricted Rats

Moderate calorie restriction (CR) (∼60% of ad libitum, AL, intake) has been associated with numerous favorable physiological outcomes in many species, and the insulin/IGF-1 and mTOR signaling pathways have each been proposed as potential mediators for many of CR's bioeffects. However, few studi...

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Autors principals: Sharma, Naveen, Castorena, Carlos M., Cartee, Gregory D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368930/
https://ncbi.nlm.nih.gov/pubmed/22701721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038835
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