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Mitochondrial regulation of epigenetics and its role in human diseases

Most pathogenic mitochondrial DNA (mtDNA) mutations induce defects in mitochondrial oxidative phosphorylation (OXPHOS). However, phenotypic effects of these mutations show a large degree of variation depending on the tissue affected. These differences are difficult to reconcile with OXPHOS as the so...

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Detalhes bibliográficos
Main Authors: Minocherhomji, Sheroy, Tollefsbol, Trygve O., Singh, Keshav K.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368816/
https://ncbi.nlm.nih.gov/pubmed/22419065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.19547
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