In Vivo Evaluation of Limiting Brain Penetration of Probes for α(2C)-Adrenoceptor Using Small-Animal Positron Emission Tomography

[Image: see text] To evaluate in vivo brain penetration of α(2C)-adrenoceptor (α(2C)-AR) antagonists as a therapeutic agent, we synthesized two new (11)C-labeled selective α(2C)-AR antagonists 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl-2-aryl-7-methoxybenzofuran ([(11)C]MBF) and acri...

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Autors principals: Kawamura, Kazunori, Akiyama, Megumi, Yui, Joji, Yamasaki, Tomoteru, Hatori, Akiko, Kumata, Katsushi, Wakizaka, Hidekatsu, Takei, Makoto, Nengaki, Nobuki, Yanamoto, Kazuhiko, Fukumura, Toshimitsu, Zhang, Ming-Rong
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368684/
https://ncbi.nlm.nih.gov/pubmed/22778842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn1000364
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