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Selective Acetylcholinesterase Inhibitor Activated by Acetylcholinesterase Releases an Active Chelator with Neurorescuing and Anti-Amyloid Activities
[Image: see text] The finding that acetylcholinesterase (AChE) colocalizes with β-amyloid (Aβ) and promotes and accelerates Aβ aggregation has renewed an intense interest in developing new multifunctional AChE inhibitors as potential disease-modifying drugs for Alzheimer’s therapy. To this end, we h...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2010
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3368637/ https://ncbi.nlm.nih.gov/pubmed/22778810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100069c |
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