pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system

BACKGROUND: In this study, a pH and temperature dual-sensitive liposome gel based on a novel cleavable hydrazone-based pH-sensitive methoxy polyethylene glycol 2000-hydrazone-cholesteryl hemisuccinate (mPEG-Hz-CHEMS) polymer was used for vaginal administration. METHODS: The pH-sensitive, cleavable m...

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Detalhes bibliográficos
Main Authors: Chen, Daquan, Sun, Kaoxiang, Mu, Hongjie, Tang, Mingtan, Liang, Rongcai, Wang, Aiping, Zhou, Shasha, Sun, Haijun, Zhao, Feng, Yao, Jianwen, Liu, Wanhui
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368511/
https://ncbi.nlm.nih.gov/pubmed/22679372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S31757
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