Diazepam-bound GABA(A) receptor models identify new benzodiazepine binding-site ligands

Benzodiazepines exert their anxiolytic, anticonvulsant, muscle-relaxant and sedative-hypnotic properties by allosterically enhancing the action of GABA at GABA(A) receptors via their benzodiazepine-binding site. Although these drugs have been used clinically since 1960, the molecular basis of this i...

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Main Authors: Richter, Lars, de Graaf, Chris, Sieghart, Werner, Varagic, Zdravko, Mörzinger, Martina, de Esch, Iwan J P, Ecker, Gerhard F, Ernst, Margot
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368153/
https://ncbi.nlm.nih.gov/pubmed/22446838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.917
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