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Switch II Mutants Reveal Coupling between the Nucleotide- and Actin-Binding Regions in Myosin V
Conserved active-site elements in myosins and other P-loop NTPases play critical roles in nucleotide binding and hydrolysis; however, the mechanisms of allosteric communication among these mechanoenzymes remain unresolved. In this work we introduced the E442A mutation, which abrogates a salt-bridge...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3368122/ https://ncbi.nlm.nih.gov/pubmed/22713570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.04.025 |
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