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Visualization of Genomic Changes by Segmented Smoothing Using an L (0) Penalty

Copy number variations (CNV) and allelic imbalance in tumor tissue can show strong segmentation. Their graphical presentation can be enhanced by appropriate smoothing. Existing signal and scatterplot smoothers do not respect segmentation well. We present novel algorithms that use a penalty on the [I...

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Detalhes bibliográficos
Main Authors: Rippe, Ralph C. A., Meulman, Jacqueline J., Eilers, Paul H. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367998/
https://ncbi.nlm.nih.gov/pubmed/22679492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038230
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