ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production

Inflammation and oxidative stress play a crucial role in angiotensin (Ang) II-mediated vascular injury. Angiotensin-converting enzyme 2 (ACE2) has recently been identified as a specific Ang II-degrading enzyme but its role in vascular biology remains elusive. We hypothesized that loss of ACE2 would...

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Autori principali: Jin, Hai-Yan, Song, Bei, Oudit, Gavin Y., Davidge, Sandra T., Yu, Hui-Min, Jiang, Yan-Yan, Gao, Ping-Jin, Zhu, Ding-Liang, Ning, Guang, Kassiri, Zamaneh, Penninger, Josef M., Zhong, Jiu-Chang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367919/
https://ncbi.nlm.nih.gov/pubmed/22693641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038502
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