Mitochondrial Physiology and Gene Expression Analyses Reveal Metabolic and Translational Dysregulation in Oocyte-Induced Somatic Nuclear Reprogramming

While reprogramming a foreign nucleus after somatic cell nuclear transfer (SCNT), the enucleated oocyte (ooplasm) must signal that biomass and cellular requirements changed compared to the nucleus donor cell. Using cells expressing nuclear-encoded but mitochondria-targeted EGFP, a strategy was devel...

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Main Authors: Esteves, Telma C., Psathaki, Olympia E., Pfeiffer, Martin J., Balbach, Sebastian T., Zeuschner, Dagmar, Shitara, Hiroshi, Yonekawa, Hiromichi, Siatkowski, Marcin, Fuellen, Georg, Boiani, Michele
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367913/
https://ncbi.nlm.nih.gov/pubmed/22693623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036850
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