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Deletion-Mutant mtDNA Increases in Somatic Tissues but Decreases in Female Germ Cells With Age
The proportions of mutant and wild-type mtDNA are crucial in determining the severity of mitochondrial diseases. It has been generally considered that deletion-mutant mtDNA has replication advantages and accumulates with time. Here, we examine the tissue-by-tissue proportions of mutant mtDNA with a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2219472/ https://ncbi.nlm.nih.gov/pubmed/18073422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.081026 |
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