IL-2 and IL-4 Stimulate MEK1 Expression and Contribute to T Cell Resistance against Suppression by TGF-β and IL-10 in Asthma

The T cell-driven airway inflammation in chronic asthma is uninhibited and sustained. We examined the resistance of T cells from asthmatic patients against suppression by TGF-β, IL-10 and glucocorticoids and explored its signaling mechanism. CD4(+)CD25(−) T cells from allergic asthmatic subjects dem...

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Main Authors: Liang, Qiaoling, Guo, Lei, Gogate, Shaila, Karim, Zunayet, Hanifi, Arezoo, Leung, Donald Y., Gorska, Magdalena M., Alam, Rafeul
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367768/
https://ncbi.nlm.nih.gov/pubmed/20926789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000690
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