Nuclear Translocation of MEK1 Triggers a Complex T cell Response through the Co-repressor Silencing Mediator of Retinoid and Thyroid Hormone Receptor (SMRT)

MEK1 phosphorylates ERK1/2 and regulates T cell generation, differentiation and function. MEK1 has recently been shown to translocate to the nucleus. Its nuclear function is largely unknown. By studying human CD4 T cells we demonstrate that a low level of MEK1 is present in the nucleus of CD4 T cell...

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Autores principales: Guo, Lei, Chen, Chaoyu, Liang, Qiaoling, Karim, Md. Zunayet, Gorska, Magdalena M., Alam, Rafeul
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530839/
https://ncbi.nlm.nih.gov/pubmed/23225884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201657
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