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Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype
There has been considerable interest in targeting cell cycle checkpoints particularly in emerging and alternative anticancer strategies. Here, we show that checkpoint abrogation by AZD7762, a potent and selective CHK1/2 kinase inhibitor enhances genotoxic treatment efficacy in immature KG1a leukemic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367716/ https://ncbi.nlm.nih.gov/pubmed/22258035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.13.5.19074 |
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