Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy

BACKGROUND: 5-Aminolevulinic acid (ALA) and its derivatives have been widely used in photodynamic therapy. The main drawback associated with ALA-based photodynamic therapy (ALA-PDT) and ALA fluorescence diagnosis results from the hydrophilic nature of ALA and lack of selectivity for tumor versus non...

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Bibliographic Details
Main Authors: Johnson, Renjith P, Chung, Chung-Wook, Jeong, Young-Il, Kang, Dae Hwan, Suh, Hongsuk, Kim, Il
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2012
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367496/
https://ncbi.nlm.nih.gov/pubmed/22679363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S29582
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