Nanoparticle-Mediated Delivery of shRNA.VEGF-A Plasmids Regresses Corneal Neovascularization

PURPOSE. To determine the efficacy of a plasmid containing a small hairpin RNA expression cassette (pSEC.shRNA) against VEGF-A–loaded poly(lactic co-glycolic acid) nanoparticles (PLGA NPs) in the sustained regression of murine corneal neovascularization. METHODS. PLGA nanoparticles were loaded with...

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Главные авторы: Qazi, Yureeda, Stagg, Brian, Singh, Nirbhai, Singh, Swita, Zhang, Xiaohui, Luo, Ling, Simonis, Jacquelyn, Kompella, Uday B., Ambati, Balamurali K.
Формат: Artigo
Язык:Inglês
Опубликовано: The Association for Research in Vision and Ophthalmology 2012
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367470/
https://ncbi.nlm.nih.gov/pubmed/22467572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-9139
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