Cancer chromosomal instability: therapeutic and diagnostic challenges

Chromosomal instability (CIN)—which is a high rate of loss or gain of whole or parts of chromosomes—is a characteristic of most human cancers and a cause of tumour aneuploidy and intra-tumour heterogeneity. CIN is associated with poor patient outcome and drug resistance, which could be mediated by e...

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Bibliographic Details
Main Authors: McGranahan, Nicholas, Burrell, Rebecca A, Endesfelder, David, Novelli, Marco R, Swanton, Charles
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367245/
https://ncbi.nlm.nih.gov/pubmed/22595889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.61
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