DNA looping by FokI: the impact of synapse geometry on loop topology at varied site orientations

Most restriction endonucleases, including FokI, interact with two copies of their recognition sequence before cutting DNA. On DNA with two sites they act in cis looping out the intervening DNA. While many restriction enzymes operate symmetrically at palindromic sites, FokI acts asymmetrically at a n...

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Bibliographic Details
Main Authors: Rusling, David A., Laurens, Niels, Pernstich, Christian, Wuite, Gijs J. L., Halford, Stephen E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367207/
https://ncbi.nlm.nih.gov/pubmed/22362745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks183
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