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Investigating the entire course of telithromycin binding to Escherichia coli ribosomes
Applying kinetics and footprinting analysis, we show that telithromycin, a ketolide antibiotic, binds to Escherichia coli ribosomes in a two-step process. During the first, rapidly equilibrated step, telithromycin binds to a low-affinity site (K(T) = 500 nM), in which the lactone ring is positioned...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3367204/ https://ncbi.nlm.nih.gov/pubmed/22362747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks174 |
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