Investigating the entire course of telithromycin binding to Escherichia coli ribosomes

Applying kinetics and footprinting analysis, we show that telithromycin, a ketolide antibiotic, binds to Escherichia coli ribosomes in a two-step process. During the first, rapidly equilibrated step, telithromycin binds to a low-affinity site (K(T) = 500 nM), in which the lactone ring is positioned...

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Main Authors: Kostopoulou, Ourania N., Petropoulos, Alexandros D., Dinos, George P., Choli-Papadopoulou, Theodora, Kalpaxis, Dimitrios L.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367204/
https://ncbi.nlm.nih.gov/pubmed/22362747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks174
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